San Bruno Police Chief Ed Barberini said a woman believed to be the shooter was found dead in the building with a "self-inflicted wound".
The condition of the injured, who have been taken to hospital, is unknown.
Earlier, panicked YouTube employees fled the building, in San Mateo county, south of San Francisco.
San Francisco General Hospital is treating three patients from the shooting, and one is in a critical condition, the Associated Press reports.
One employee at a nearby fast food restaurant told Fox station KTVU he had treated a young woman who suffered a gunshot wound to the leg. He said he had fashioned a makeshift tourniquet from a bungee cord as they waited for first responders.
Some 1,700 people work at the YouTube HQ.
Images broadcast on local TV stations showed employees leaving with their hands raised. Other footage appeared to show evacuees forming a queue before being individually frisked by police.
Mr Barberini said police arrived at the scene at 12:48 (19:48 GMT) local time after receiving many 911 calls reporting gunshots.
He said officers were faced with "numerous employees fleeing". One victim with a gunshot wound was found at the front of the company headquarters, he said.
YouTube product manager Todd Sherman earlier tweeted that people fled the building in panic.
We were sitting in a meeting and then we heard people running because it was rumbling the floor. First thought was earthquake. https://t.co/gmolQmRXm1— Todd Sherman (@tdd) April 3, 2018
Another employee, Vadim Lavrusik, initially tweeted he was barricaded in a room with other staff. He later said he had been evacuated.
Active shooter at YouTube HQ. Heard shots and saw people running while at my desk. Now barricaded inside a room with coworkers.— Vadim Lavrusik (@Lavrusik) April 3, 2018
California Senator Dianne Feinstein tweeted that she was praying for the safety of those at the scene.
My stomach sinks with yet another active shooter alert. I’m praying for the safety of everyone at YouTube headquarters.— Sen Dianne Feinstein (@SenFeinstein) April 3, 2018
Source: BBC
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