Osmanlispor (TUR) 0 Olympiakos (GRE) 3 (Ansarifard 47, 86, Elyounoussi 70)
Olympiakos go through 3-0 on aggregate
Ajax (NED) 1 ((Viergever 49) Legia Warsaw (POL) 0
Ajax go through 1-0 on aggregate
APOEL (CYP) 2 (Sotiriou 46, Gianniotas 54-pen) Athletic Bilbao (ESP) 0
APOEL go through 4-3 on aggregate
Zenit Saint Petersburg (RUS) 3 (Giuliano 24, 78, Dzyuba 72) Anderlecht (BEL) 1 (Thelin 90)
Aggregate 3-3 – Anderlecht go through on away goals
Roma (ITA) 0 Villarreal (ESP) 1 (Borré Amaury 16)
Roma go through 4-1 on aggregate
Besiktas (TUR) 2 (Aboubakar 17, Tosun 87) Hapoel Beer-Sheva (ISR) 1 (Nwakaeme 64)
Besiktas go through lead 5-2
Playing later
Fiorentina (ITA) v Borussia Moenchengladbach (GER)
(Fiorentina lead 1-0)
Sparta Prague (CZE) v Rostov (RUS)
(Rostov lead 4-0)
Tottenham Hotspur (ENG) v Gent (BEL)
(Gent lead 1-0)
Shakhtar Donetsk (UKR) v Celta Vigo (ESP)
(Shakhtar lead 1-0)
Copenhagen (DEN) v Ludogorets (BUL)
(Copenhagen lead 2-1)
Genk (BEL) v Astra Giurgiu (ROM)
(Level at 2-2)
Lyon (FRA) v AZ Alkmaar (NED)
(Lyon lead 4-1)
Played Wednesday
Saint-Etienne (FRA) 0 Manchester United (ENG) 1 (Mkhitaryan 16)
(United win 4-0 on aggregate)
Schalke (GER) 1 (Schopf 23) PAOK (GRE) 1 (Nastasic 25-og)
Schalke win 4-1 on aggregate
Fenerbahce (TUR) 1 (Souza 41) Krasnodar (RUS) 1 (Smolov 7)
(Krasnodar win 2-1 on aggregate)
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